解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein. FHIT is frequently abnormal in solid tumours including those of the upper aerodigestive tract (UAT) and has therefore been proposed as a tumour-suppressor gene. T...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00062-7
更新日期:2000-03-01 00:00:00
abstract::We investigated the presence of neural cell adhesion molecule (N-CAM) in the adenoid cystic carcinoma cell line CAC2 using immunofluorescence microscopy. Additionally, we analysed the role of laminin and type IV collagen in N-CAM expression. We demonstrated that cultured adenoid cystic carcinoma cells express N-CAM. C...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00087-1
更新日期:2000-03-01 00:00:00
abstract::Knowledge about the influence of biomarkers on cell proliferative activity might explain differences in radiosensitivity between head and neck tumors and might improve patient selection for the most optimal treatment strategy. p53 and bcl-2 protein expression were determined immunohistochemically in 56 head and neck c...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00051-2
更新日期:2000-01-01 00:00:00
abstract::Forty-four patients with head and neck malignancies were included in a prospective, randomized, double-blind, placebo-controlled study for evaluation of sucralfate in prevention of oral mucositis induced by radiation therapy. Patients were randomized to receive oral suspensions of either sucralfate (n = 23) or placebo...
journal_title:Oral oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s1368-8375(99)00075-5
更新日期:2000-01-01 00:00:00
abstract::Laryngeal cancer is a rare type of neoplasia, constituting approximately 2% of all human cancers. Mutations of the ras gene family is one of the main activating mechanisms in human cancer. Their involvement in head and neck cancer has been mainly demonstrated at the level of the overexpression whereas ras mutations in...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00032-9
更新日期:1999-11-01 00:00:00
abstract::Tissue eosinophilia in squamous cell carcinoma has long been recognized; however, the role of eosinophils in tumor development remains unclear. Studies have reported both favorable and unfavorable prognoses for patients with tumors exhibiting tumor-associated tissue eosinophilia (TATE). This study seeks to elucidate t...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00023-8
更新日期:1999-09-01 00:00:00
abstract::The hormonal regulation of Na+,K(+)-ATPase enzyme activities and induction of the alpha subunit protein of the enzyme in the human submandibular gland (HSG) were studied by use of cultured HSG cells. We treated HSG cells with thyroid hormone, androgen, mineralocorticoid, and glucocorticoid, singly or in combination. 3...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00124-9
更新日期:1999-07-01 00:00:00
abstract::Oral malignant melanoma is uncommon, accounting for 1-8% of all malignant melanomas. All previous papers have reported small numbers of cases or have retrospectively reviewed case reports from the literature. The following case reports concern malignant melanoma of the oral cavity seen at the Instituto Nacional de Can...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(99)00017-2
更新日期:1999-07-01 00:00:00
abstract::Overexpression of the epidermal growth factor (EGF) receptor, a hallmark of aerodigestive squamous cell carcinoma of the head and neck (SCCHN), correlates with aggressive tumor behavior. There is evidence that SCCHN cells auto-activate their EGF receptors. The receptor has therefore attracted interest as a potential t...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00118-3
更新日期:1999-05-01 00:00:00
abstract::A series of patients with oral squamous cell carcinoma (SCC) observed at the "Regina Elena" Cancer Institute was retrospectively reviewed in order to analyse the risk factors for multiple and second primary tumours (SPTs), their impact on survival and effective measures to control this phenomenon. In a survey of 200 i...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00105-5
更新日期:1999-03-01 00:00:00
abstract::p53 is a transcription factor which regulates cell proliferation and apoptosis to prevent division of potentially malignant cells. In many tumours mutation of the p53 gene leads to stabilisation of this protein which can be detected by immunohistochemistry (IHC). However, there are many reports describing detection of...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00051-7
更新日期:1999-01-01 00:00:00
abstract::A new photosensitizing agent 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) has been demonstrated as a useful method for treatment of superficial neoplastic lesions. The aim of this study was to determine the effects of topically and systemically ALA-based PDT in neoplastic lesions of the oral cavity. Pr...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00066-9
更新日期:1999-01-01 00:00:00
abstract::We established a new evaluation system for metastatic potential of oral squamous cell carcinoma (SCC), utilizing a combined examination of histopathological grades of the carcinomas based on cell differentiation and invasive mode according to Yamamoto's criteria, and the cellular expressions of CD44, E-cadherin (E-cad...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00048-7
更新日期:1998-11-01 00:00:00
abstract::The distributions of 2093 patients with nasopharyngeal carcinoma (NPC), by stage, over a 12-year-period did not show any evidence of a shift towards early stages despite growing awareness of this prevalent malignancy. The IgA VCA titre was determined for 1880 of these patients. The median titre increased from 40 in st...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00063-3
更新日期:1998-11-01 00:00:00
abstract::The identification of the proliferative activity in tumours may be useful to predict the biological behaviour of different lesions. Proliferating cell nuclear antigen (PCNA) has been used for the evaluation of the proliferative ability of many lesions. In this study 22 ameloblastomas (4 follicular, 5 plexiform, 4 acan...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00027-x
更新日期:1998-09-01 00:00:00
abstract::p21waf1/cip1 protein, an inhibitor of cyclin dependent kinases, is a critical downstream target in the p53-specific pathway of growth control, and can also be induced by p53 independent pathways in relation to terminal differentiation. p21waf1 is also a putative tumour suppressor. Hence, we sought to determine whether...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(98)00021-9
更新日期:1998-09-01 00:00:00
abstract::Cytokeratin (CK) expression was studied in buccal mucosa (BM) from 20 leucoplakia and 7 submucous fibrosis patients using sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), immunoblotting and two-dimensional gel electrophoresis with iso-electric focussing (IEF) as the first dimension. Normal BM exp...
journal_title:Oral oncology
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::Quality of life evaluation is an important measure of outcome following the treatment of head and neck cancer. The aim of this study was to evaluate the quality of life of patients undergoing primary surgery for oral and oropharyngeal squamous cell carcinoma. 50 consecutive patients with previously untreated oral canc...
journal_title:Oral oncology
pub_type: 临床试验,杂志文章
doi:10.1016/s1368-8375(97)00069-9
更新日期:1998-05-01 00:00:00
abstract::An intravenous pseudotumour at a traumatised site of the buccal mucosa of a 68-year-old woman is described. The lesion was composed of reactive spindle cell proliferation, merging of haphazard bizarre cells and inflammatory elements. Cellular morphology and immunohistochemical profile of proliferating cells reflected ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(97)00080-8
更新日期:1998-05-01 00:00:00
abstract::To understand the role of 70 kDa heat shock protein (HSP70) in the pathogenesis of oral cancer, its expression was studied in human normal, premalignant and malignant oral mucosa. Cell surface expression of HSP70 was assessed in oral tissue specimens by flow cytometric analysis using a mouse monoclonal antibody agains...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(97)00055-9
更新日期:1998-03-01 00:00:00
abstract::Cell lines developed from head and neck squamous cell carcinomas exhibit variable responses to the negative regulatory effects of transforming growth factor beta (TGF beta) on cell growth. To analyse the effects of TGF beta on regulators of cell cycle progression, we characterised cell lines derived from head and neck...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(97)00023-7
更新日期:1998-01-01 00:00:00
abstract::Integrins are a family of heterodimeric, cation-dependent cell membrane adhesion molecules which mediate cell-cell and cell-matrix interactions. They play a fundamental role in the maintenance of tissue integrity and in the regulation of cell proliferation, growth, differentiation and migration. It is not surprising, ...
journal_title:Oral oncology
pub_type: 杂志文章,评审
doi:10.1016/s0964-1955(97)00021-3
更新日期:1997-11-01 00:00:00
abstract::Ameloblastic fibro-odontoma is a rare odontogenic tumour. It affects young people and is usually located in the posterior jaws. Two cases of this tumour are presented: both lesions had produced an asymptomatic swelling. The histology showed the presence of an odontogenic epithelium immersed in a fibrous mesenchyme; de...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(97)00046-8
更新日期:1997-11-01 00:00:00
abstract::The present investigation has examined the clinical benefits of tobramycin, polymyxin E and amphotericin therapy in the management of oral mucositis in children undergoing chemotherapy prior to bone marrow transplantation. Tobramycin, polymyxin E, and amphotericin reduced the degree of oral mucositis more than convent...
journal_title:Oral oncology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s1368-8375(97)00039-0
更新日期:1997-09-01 00:00:00
abstract::Traumatic eosinophilic granuloma of the oral mucosa, also known as eosinophilic ulcer, is considered to be a reactive lesion of unknown aetiology. It usually presents as a tongue ulcer and injury has been considered to play a role in its cause. We present a 72-year-old man who had suffered multiple episodes of recurre...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s1368-8375(97)00014-6
更新日期:1997-09-01 00:00:00
abstract::A unique case of bilateral mucoepidermoid carcinoma arising in pre-existing bilateral Warthin's tumours of the parotid glands is presented. Reports of carcinomas arising in pre-existing unilateral Warthin's tumours are likewise rare with only 3 cases of concern mucoepidermoid carcinoma. This is the first report of bil...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(97)00018-3
更新日期:1997-07-01 00:00:00
abstract::Acinic cell carcinoma (ACC) is a rare salivary gland tumour, making up 4% of all minor salivary gland tumors. Typically, it is composed of acinic cells although transitional and duct-like cells are also identified. In the present study, a panel of antibodies was applied to eight minor salivary gland ACCs. Antibodies t...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(96)00064-4
更新日期:1997-05-01 00:00:00
abstract::Verrucous carcinomas are considered to have poor radioresponsiveness and radiotherapy has been reported to induce anaplastic transformation. Surgery has been considered to be the primary mode of treatment for these tumours. The clinical features, response to radiotherapy, survival and prognostic factors of a group of ...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(96)00059-0
更新日期:1997-03-01 00:00:00
abstract::Immunoreactivity of proliferating cell nuclear antigen (PCNA) was assessed in formalin-fixed, paraffin-embedded sections from human normal parotid gland (N; n = 12), chronic sialadenitis (CS; n = 8), Warthin's tumour (W; n = 10), benign pleomorphic adenoma (BPA; n = 11), mucoepidermoid carcinoma (MEC; n = 14), carcino...
journal_title:Oral oncology
pub_type: 杂志文章
doi:10.1016/s0964-1955(96)00038-3
更新日期:1997-01-01 00:00:00